Ontology highlight
ABSTRACT:
SUBMITTER: McGirr A
PROVIDER: S-EPMC7026117 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
McGirr Alexander A LeDue Jeffrey J Chan Allen W AW Boyd James D JD Metzak Paul D PD Murphy Timothy H TH
Translational psychiatry 20200121 1
Medically unexplained symptoms in depression are common. These individual-specific complaints are often considered an 'idiom of distress', yet animal studies suggest that cortical sensory representations are flexible and influenced by spontaneous cortical activity. We hypothesized that stress would reveal activity dynamics in somatosensory cortex resulting in greater sensory-evoked response variability. Using millisecond resolution in vivo voltage sensitive dye (VSD) imaging in mouse neocortex, ...[more]