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Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial.

ABSTRACT: Few randomized controlled trials investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Furthermore, there have been hypotheses and theoretical mechanisms on the benefits of mindfulness intervention on biomarkers of stress, inflammation, and neuroplasticity implicated in MCI that warrant empirical evidence. We conducted a pilot randomized controlled trial to examine whether Mindful Awareness Practice (MAP) improved biomarker levels in older adults with MCI. Fifty-five community-dwelling older adults aged 60 and above were randomized into either the treatment arm, MAP, or the active control arm, the health education program (HEP). Researchers who were blinded to treatment allocation assessed the outcomes at baseline, 3-month, and 9-month follow-ups. Linear-mixed models were used to examine the effect of MAP on biomarker levels. MAP participants had significantly decreased high-sensitivity c-reactive protein (hs-CRP) levels at 9-month (??=?-0.307, 95% CI?=?-0.559 to -0.054 P?=?0.018). Exploratory sub-group analyses by sex showed significantly decreased hs-CRP in females only (??=?-0.445, 95% CI?=?-0.700 to -0.189, P?=?0.001), while stratification by MCI subtype showed hs-CRP decreased only in amnestic-MCI (aMCI) (??=?-0.569, 95% CI?=?-1.000 to -0.133, P?=?0.012). Although total sample analyses were not significant, males had significantly decreased interleukin (IL)-6 (??=?-1.001, 95% CI?=?-1.761 to -0253, P?=?0.011) and IL-1? (??=?-0.607, 95% CI?=?-1.116 to -0.100, P?=?0.021) levels at 3-month and non-significant improvements at 9-month time-point. MAP improved inflammatory biomarkers in sex- and MCI subtype-specific manners. These preliminary findings suggest the potential of mindfulness intervention as a self-directed and low-cost preventive intervention in improving pathophysiology implicated in MCI.

SUBMITTER: Ng TKS

PROVIDER: S-EPMC7026149 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial.

Ng Ted Kheng Siang TKS Fam Johnson J Feng Lei L Cheah Irwin Kee-Mun IK Tan Crystal Tze-Ying CT Nur Fadzillah F Wee Sin Tho ST Goh Lee Gan LG Chow Wei Ling WL Ho Roger Chun-Man RC Kua Ee Heok EH Larbi Anis A Mahendran Rathi R

Translational psychiatry 20200121 1

Few randomized controlled trials investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Furthermore, there have been hypotheses and theoretical mechanisms on the benefits of mindfulness intervention on biomarkers of stress, inflammation, and neuroplasticity implicated in MCI that warrant empirical evidence. We conducted a pilot randomized controlled trial to examine whether Mindful Awareness Practice (MAP) improved biomarker levels in ...[more]

PMID: 32066726

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Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial.

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Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial.

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