In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha.

ABSTRACT: Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α susceptibility and productivity of infectious transmitted/founder (TF) (n = 8) and non-transmitted (NT) viruses (n = 8) derived from HIV-1 infected infants. Independent experiments were carried out to determine IFN-α resistance, replication fitness, and viral productivity in CD4⁺ T cells over a short period. In vitro studies showed that TF viruses were resistant to IFN-α during the very near moment of transmission, but in the subsequent time points, they became suscept

SUBMITTER: Ashokkumar M 

PROVIDER: S-EPMC7026412 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature