Ontology highlight
ABSTRACT:
SUBMITTER: Henderson MX
PROVIDER: S-EPMC7026836 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Henderson Michael X MX Covell Dustin J DJ Chung Charlotte Hiu-Yan CH Pitkin Rose M RM Sandler Raizel M RM Decker Samantha C SC Riddle Dawn M DM Zhang Bin B Gathagan Ronald J RJ James Michael J MJ Trojanowski John Q JQ Brunden Kurt R KR Lee Virginia M Y VMY Luk Kelvin C KC
Neurobiology of disease 20191216
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there is compelling evidence to suggest that progression of these diseases is associated with the trans-cellular spread of pathogenic α-synuclein through the brains of afflicted individuals. Therapies targeting extracellular, pathogenic α-synuclein may therefo ...[more]