Ontology highlight
ABSTRACT:
SUBMITTER: Akama T
PROVIDER: S-EPMC7026885 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Akama Tsutomu T Freund Yvonne R YR Berry Pamela W PW Carter David S DS Easom Eric E EE Jarnagin Kurt K Lunde Christopher S CS Plattner Jacob J JJ Rock Fernando F Stefanakis Rianna R Fischer Chelsea C Bulman Christina A CA Lim Kee Chong KC Suzuki Brian M BM Tricoche Nancy N Mansour Abdelmoneim A DiCosty Utami U McCall Scott S Carson Ben B McCall John W JW McKerrow James J Hübner Marc P MP Specht Sabine S Hoerauf Achim A Lustigman Sara S Sakanari Judy A JA Jacobs Robert T RT
ACS infectious diseases 20200114 2
A series of benzimidazole-benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good <i>in vitro</i> activity against <i>Onchocerca volvulus</i>, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness. The lead identified in this series, <b>8a</b> (AN8799), was found to have acceptable pharmacokinetic properties to enable evaluation in animal models of human filariasis. Compound <b>8a</b> was effective in killing <i>Brugia mal ...[more]