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Endurance exercise leads to beneficial molecular and physiological effects in a mouse model of myotonic dystrophy type 1.

ABSTRACT: Introduction:Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by expansion of a CTG repeat in the 3' UTR of the Dystrophia Myotonica-Protein Kinase (DMPK) gene. While multiple organs are affected, more than half of mortality is due to muscle wasting.

Methods:It is unclear whether endurance exercise provides beneficial effects in DM1. Here, we show that a 10-week treadmill endurance exercise program leads to beneficial effects in the HSA^LR mouse model of DM1.

Results:Animals that performed treadmill training displayed reduced CUGexp RNA levels, improved splicing abnormalities, an increase in skeletal muscle weight and improved endurance capacity.

Discussion:These results indicate that endurance exercise does not have adverse effects in HSA^LR animals and contributes to beneficial molecular and physiological outcomes.

SUBMITTER: Sharp L

PROVIDER: S-EPMC7026901 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Endurance exercise leads to beneficial molecular and physiological effects in a mouse model of myotonic dystrophy type 1.

Sharp Lydia L Cox Diana C DC Cooper Thomas A TA

Muscle & nerve 20191023 6

<h4>Introduction</h4>Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by expansion of a CTG repeat in the 3' UTR of the Dystrophia Myotonica-Protein Kinase (DMPK) gene. While multiple organs are affected, more than half of mortality is due to muscle wasting.<h4>Methods</h4>It is unclear whether endurance exercise provides beneficial effects in DM1. Here, we show that a 10-week treadmill endurance exercise program leads to beneficial effects in the HSA<sup>LR</sup> mouse model of ...[more]

PMID: 31509256

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