Ontology highlight
ABSTRACT:
SUBMITTER: Kong FQ
PROVIDER: S-EPMC7027125 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Kong Fan-Qi FQ Zhao Shu-Jie SJ Sun Peng P Liu Hao H Jie Jian J Xu Tao T Xu An-Di AD Yang Ya-Qing YQ Zhu Ye Y Chen Jian J Zhou Zheng Z Qian Ding-Fei DF Gu Chang-Jiang CJ Chen Qi Q Yin Guo-Yong GY Zhang Han-Wen HW Fan Jin J
Journal of neuroinflammation 20200217 1
<h4>Background</h4>A sustained inflammatory response following spinal cord injury (SCI) contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major participants in the inflammatory response, transform into foamy macrophages after phagocytosing myelin debris, subsequently releasing inflammatory factors and amplifying the secondary injury. Here, we assessed the effect of macrophage scavenger receptor 1 (MSR1) in phagocytosis of myelin debris after SCI and explained its p ...[more]