Future prospects for CD8+ regulatory T cells in immune tolerance.
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ABSTRACT:
SUBMITTER: Flippe L
PROVIDER: S-EPMC7027528 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Future prospects for CD8<sup>+</sup> regulatory T cells in immune tolerance.
Flippe Léa L Bézie Séverine S Anegon Ignacio I Guillonneau Carole C
Immunological reviews 20191008 1
CD8<sup>+</sup> Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4<sup>+</sup> Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8<sup>+</sup> and CD4<sup>+</sup> Tregs, and we will discuss the biology, developme ...[more]
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