Ontology highlight
ABSTRACT:
SUBMITTER: Chavassieux P
PROVIDER: S-EPMC7027577 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Chavassieux Pascale P Chapurlat Roland R Portero-Muzy Nathalie N Roux Jean-Paul JP Garcia Pedro P Brown Jacques P JP Libanati Cesar C Boyce Rogely W RW Wang Andrea A Grauer Andreas A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20190624 9
Sclerostin, a protein produced by osteocytes, inhibits bone formation. Administration of sclerostin antibody results in increased bone formation in multiple animal models. Romosozumab, a humanized sclerostin antibody, has a dual effect on bone, transiently increasing serum biochemical markers of bone formation and decreasing serum markers of bone resorption, leading to increased BMD and reduction in fracture risk in humans. We aimed to evaluate the effects of romosozumab on bone tissue. In a sub ...[more]