Ontology highlight
ABSTRACT:
SUBMITTER: Gilat M
PROVIDER: S-EPMC7027846 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Gilat Moran M Coeytaux Jackson Alessandra A Marshall Nathaniel S NS Hammond Deborah D Mullins Anna E AE Hall Julie M JM Fang Bernard A M BAM Yee Brendon J BJ Wong Keith K H KKH Grunstein Ron R RR Lewis Simon J G SJG
Movement disorders : official journal of the Movement Disorder Society 20191031 2
<h4>Background</h4>Melatonin may reduce REM-sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking.<h4>Objective</h4>To assess the efficacy of prolonged-release (PR) melatonin for RBD in PD.<h4>Methods</h4>Randomized, double-blind, placebo-controlled, parallel-group trial with an 8-week intervention and 4-week observation pre- and postintervention (ACTRN12613000648729). Thirty PD patients with rapid eye movement sleep behavior disorder were ...[more]