A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols.
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ABSTRACT:
SUBMITTER: Maini Rekdal V
PROVIDER: S-EPMC7028382 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols.
Maini Rekdal Vayu V Nol Bernadino Paola P Luescher Michael U MU Kiamehr Sina S Le Chip C Bisanz Jordan E JE Turnbaugh Peter J PJ Bess Elizabeth N EN Balskus Emily P EP
eLife 20200218
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms are poorly understood. Here, we characterize a molybdenum-dependent enzyme from the human gut bacterium <i>Eggerthella lenta</i> that dehydroxylates catecholamine neurotransmitters. Our findings suggest that this activity enables <i>E. lenta</i> to use dopamine a ...[more]
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