Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC7028398 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zhang Jiantao J Hu Yanmei Y Wu Nan N Wang Jun J
ACS chemical biology 20191121 1
The limited therapeutic options and increasing drug-resistance call for next-generation influenza antivirals. Due to the essential function in viral replication and high sequence conservation among influenza viruses, influenza polymerase PA-PB1 protein-protein interaction becomes an attractive drug target. Here, we developed an <i>in vitro</i> split luciferase complementation-based assay to speed up screening of PA-PB1 interaction inhibitors. By screening 10,000 compounds, we identified two PA-P ...[more]