Ontology highlight
ABSTRACT:
SUBMITTER: Derman BA
PROVIDER: S-EPMC7028458 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Derman Benjamin A BA Streck Mitchell M Wynne Joseph J Christ Trevor N TN Curran Emily E Stock Wendy W Knoebel Randall W RW
Leukemia & lymphoma 20191104 3
Incorporation of asparaginase (ASNase) and pegylated asparaginase (PEG-ASP) into pediatric-inspired regimens for adults with acute lymphoblastic leukemia (ALL) has led to improved treatment outcomes albeit with increased toxicities. This study compared the efficacy and safety of the Children's Oncology Group standard PEG-ASP (SD) dosing (>1000, median 2500 IU/m<sup>2</sup>/dose) in adult Philadelphia chromosome-negative ALL patients receiving multiagent chemotherapy vs reduced dose PEG-ASP (RED) ...[more]