Ontology highlight
ABSTRACT:
SUBMITTER: Cheesman R
PROVIDER: S-EPMC7028797 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cheesman R R Coleman J J Rayner C C Purves K L KL Morneau-Vaillancourt G G Glanville K K Choi S W SW Breen G G Eley T C TC
Behavior genetics 20191204 2
Genome-wide studies often exclude family members, even though they are a valuable source of information. We identified parent-offspring pairs, siblings and couples in the UK Biobank and implemented a family-based DNA-derived heritability method to capture additional genetic effects and multiple sources of environmental influence on neuroticism and years of education. Compared to estimates from unrelated individuals, total heritability increased from 10 to 27% and from 17 to 56% for neuroticism a ...[more]