Structural characterization of Kannurin isoforms and evaluation of the role of β-hydroxy fatty acid tail length in functional specificity.

ABSTRACT: The novel anti-fungal cyclic lipopeptide 'Kannurin' and its three structural variants produced by Bacillus cereus AK1 were previously reported from our laboratory. The present study reports unexplored structural variants of Kannurin those have functional benefits. Due to the difference in β-hydroxy fatty acid tail length, they are designated here as Kannurin A (m/z 994.67 ± 0.015), B (m/z 1008.68 ± 0.017), C (m/z 1022.69 ± 0.021), D (m/z 1036.70 ± 0.01), C_L (m/z 1040.71 ± 0.02) and D_L (m/z 1054.72 ± 0.01). The isoform A (m/z 994.67 ± 0.015) is the shortest cyclic form of Kannurin identified so far. In addition, C_L (m/z 1040.71 ± 0.02) and D_L (m/z 1054.72 ± 0.01) are the rare natural linear forms. The results of the antimicrobial assays deduced th

SUBMITTER: Shabeer Ali H 

PROVIDER: S-EPMC7029025 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature