Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England.
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ABSTRACT:
SUBMITTER: Marsden J
PROVIDER: S-EPMC7029276 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England.
Marsden John J White Martin M Annand Fizz F Burkinshaw Peter P Carville Serena S Eastwood Brian B Kelleher Michael M Knight Jonathan J O'Connor Rosanna R Tran Anh A Willey Peter P Greaves Felix F Taylor Stephen S
The lancet. Psychiatry 20191003 11
<h4>Background</h4>Antidepressants, opioids for non-cancer pain, gabapentinoids (gabapentin and pregabalin), benzodiazepines, and Z-drugs (zopiclone, zaleplon, and zolpidem) are commonly prescribed medicine classes associated with a risk of dependence or withdrawal. We aimed to review the evidence for these harms and estimate the prevalence of dispensed prescriptions, their geographical distribution, and duration of continuous receipt using all patient-linked prescription data in England.<h4>Met ...[more]
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