Unknown

Dataset Information

0

Features of ectopic lymphoid-like structures in human uveitis.


ABSTRACT: Persistent non-infectious uveitis has a significant morbidity, but the extent to which this is accompanied by inflammation driven remodelling of the tissue is unclear. To address this question, we studied a series of samples selected from two ocular tissue repositories and identified 15 samples with focal infiltration. Eleven of fifteen contained lymphocytes, both B cells (CD20 positive) and T cells (CD3 positive). In 20% of the samples there was evidence of ectopic lymphoid like structures with focal aggregations of B cells and T cells, segregated into anatomically different adjacent zones. To investigate inflammation in the tissue, an analysis of 520 immune relevant transcripts was carried out and 24 genes were differentially upregulated, compared with control tissue. Two of these (CD14 and fibronectin) were increased in ocular inflammation compared to control immune tissue (tonsil). We demonstrate that in a significant minority of patients, chronic persistent uveitis leads to dysregulation of ocular immune surveillance, characterized by the development of areas of local ectopic lymphoid like structures, which may be a target for therapeutic intervention directed at antibody producing cells.

SUBMITTER: Epps SJ 

PROVIDER: S-EPMC7029346 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Features of ectopic lymphoid-like structures in human uveitis.

Epps Simon J SJ   Coplin Natalie N   Luthert Philip J PJ   Dick Andrew D AD   Coupland Sarah E SE   Nicholson Lindsay B LB  

Experimental eye research 20191223


Persistent non-infectious uveitis has a significant morbidity, but the extent to which this is accompanied by inflammation driven remodelling of the tissue is unclear. To address this question, we studied a series of samples selected from two ocular tissue repositories and identified 15 samples with focal infiltration. Eleven of fifteen contained lymphocytes, both B cells (CD20 positive) and T cells (CD3 positive). In 20% of the samples there was evidence of ectopic lymphoid like structures with  ...[more]

Similar Datasets

2023-02-06 | GSE224596 | GEO
2015-09-25 | E-MTAB-3848 | biostudies-arrayexpress
| S-EPMC10724443 | biostudies-literature
| S-EPMC4653079 | biostudies-literature
| S-EPMC2621263 | biostudies-literature
2007-08-24 | E-SMDB-4129 | biostudies-arrayexpress
| PRJNA931932 | ENA
| S-EPMC5609563 | biostudies-literature
| S-EPMC5557391 | biostudies-literature
| S-EPMC1954653 | biostudies-literature