Ontology highlight
ABSTRACT:
SUBMITTER: Dokoshi T
PROVIDER: S-EPMC7029423 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell reports 20200101 1
Staphylococcus aureus is a major human bacterial pathogen responsible for deep tissue skin infections. Recent observations have suggested that rapid, localized digestion of hyaluronic acid in the extracellular matrix (ECM) of the dermis may influence bacterial invasion and tissue inflammation. In this study we find that cell migration-inducing protein (Cemip) is the major inducible gene responsible for hyaluronan catabolism in mice. Cemip<sup>-/-</sup> mice failed to digest hyaluronan and had si ...[more]