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Orthostatic Hypotension in Parkinson Disease.


ABSTRACT: Orthostatic hypotension (OH) is a sustained fall in blood pressure on standing that can cause symptoms of organ hypoperfusion. OH is associated with increased morbidity and mortality and leads to a significant number of hospital admissions. OH can be caused by volume depletion, blood loss, cardiac pump failure, large varicose veins, medications, or defective activation of sympathetic nerves and reduced norepinephrine release upon standing. Neurogenic OH is a frequent and disabling problem in patients with synucleinopathies such as Parkinson disease, multiple system atrophy, and pure autonomic failure, and it is commonly associated with supine hypertension. Several therapeutic options are available.

SUBMITTER: Palma JA 

PROVIDER: S-EPMC7029426 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Orthostatic Hypotension in Parkinson Disease.

Palma Jose-Alberto JA   Kaufmann Horacio H  

Clinics in geriatric medicine 20190906 1


Orthostatic hypotension (OH) is a sustained fall in blood pressure on standing that can cause symptoms of organ hypoperfusion. OH is associated with increased morbidity and mortality and leads to a significant number of hospital admissions. OH can be caused by volume depletion, blood loss, cardiac pump failure, large varicose veins, medications, or defective activation of sympathetic nerves and reduced norepinephrine release upon standing. Neurogenic OH is a frequent and disabling problem in pat  ...[more]

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