A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis.

ABSTRACT:

Background

Ubiquitin (Ub) and Ub-like proteins (Ub-L) are critical regulators of complex cellular processes such as the cell cycle, DNA repair, transcription, chromatin remodeling, signal translation, and protein degradation. Giardia intestinalis possesses an experimentally proven Ub-conjugation system; however, a limited number of enzymes involved in this process were identified using basic local alignment search tool (BLAST). This is due to the limitations of BLAST's ability to identify homologous functional regions when similarity between the sequences dips to < 30%. In addition Ub-Ls and their conjugating enzymes have not been fully elucidated in Giardia.

Objetive

To identify the enzymes involved in the Ub and Ub-Ls conjugation processes using intelligent systems based o

SUBMITTER: Castellanos IC 

PROVIDER: S-EPMC7029713 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature