Ontology highlight
ABSTRACT:
SUBMITTER: Bhaduri A
PROVIDER: S-EPMC7029801 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell stem cell 20200101 1
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor cell atlas with single-cell transcriptomics of cancer cells mapped onto a reference framework of the developing and adult human brain. We find that multiple GSC subtypes exist within a single tumor. Within these GSCs, we identify an invasive cell population similar to outer radial glia (oRG), a fetal cell type that expands t ...[more]