Ontology highlight
ABSTRACT:
SUBMITTER: Jobbagy S
PROVIDER: S-EPMC7030822 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
JCI insight 20200116 1
Lithium (Li) is the mainstay pharmacotherapeutic mood stabilizer in bipolar disorder. Its efficacious use is complicated by acute and chronic renal side effects, including nephrogenic diabetes insipidus (NDI) and progression to chronic kidney disease (CKD). The nuclear factor erythroid-derived 2-related factor 2 (Nrf2) pathway senses and coordinates cellular responses to oxidative and electrophilic stress. Here, we identify that graded genetic activation of Nrf2 protects against Li-induced NDI ( ...[more]