Ontology highlight
ABSTRACT:
SUBMITTER: Klaric L
PROVIDER: S-EPMC7030929 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Klarić Lucija L Tsepilov Yakov A YA Stanton Chloe M CM Mangino Massimo M Sikka Timo Tõnis TT Esko Tõnu T Pakhomov Eugene E Salo Perttu P Deelen Joris J McGurnaghan Stuart J SJ Keser Toma T Vučković Frano F Ugrina Ivo I Krištić Jasminka J Gudelj Ivan I Štambuk Jerko J Plomp Rosina R Pučić-Baković Maja M Pavić Tamara T Vilaj Marija M Trbojević-Akmačić Irena I Drake Camilla C Dobrinić Paula P Mlinarec Jelena J Jelušić Barbara B Richmond Anne A Timofeeva Maria M Grishchenko Alexander K AK Dmitrieva Julia J Bermingham Mairead L ML Sharapov Sodbo Zh SZ Farrington Susan M SM Theodoratou Evropi E Uh Hae-Won HW Beekman Marian M Slagboom Eline P EP Louis Edouard E Georges Michel M Wuhrer Manfred M Colhoun Helen M HM Dunlop Malcolm G MG Perola Markus M Fischer Krista K Polasek Ozren O Campbell Harry H Rudan Igor I Wilson James F JF Zoldoš Vlatka V Vitart Veronique V Spector Tim T Aulchenko Yurii S YS Lauc Gordan G Hayward Caroline C
Science advances 20200219 8
Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood about the underlying mechanisms. We performed a genome-wide association study of IgG N-glycosylation (<i>N</i> = 8090) and, using a data-driven network approach, suggested how associated loci form a functional network. We confirmed in vitro that knockdown of <i>IKZ ...[more]