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Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus.


ABSTRACT: Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted. Materials and Methods: The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics. Results: Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations. Conclusion: This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.

SUBMITTER: Liu J 

PROVIDER: S-EPMC7031205 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus.

Liu Jia J   Fan Wenliang W   Jia Yuxi Y   Su Xiaoyun X   Wu Wenjun W   Long Xi X   Sun Xin X   Liu Jie J   Sun Wengang W   Zhang Tianjing T   Gong Qiyong Q   Shi Haojun H   Zhu Qing Q   Wang Jing J  

Frontiers in endocrinology 20200213


<b>Background and Purpose:</b> Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted. <b>Materials and Methods:</b> The gray matter volume alterations in patients with T1DM was estimated by using the softw  ...[more]

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