Ontology highlight
ABSTRACT:
SUBMITTER: Hsu LH
PROVIDER: S-EPMC7031538 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hsu Li-Hang LH Kwaśniewska Dobrawa D Wang Shih-Cheng SC Shen Tang-Long TL Wieczorek Daria D Chen Ying-Lien YL
Scientific reports 20200219 1
Quaternary ammonium compounds (QACs) are classified as cationic surfactants, and are known for their biocidal activity. However, their modes of action are thus far not completely understood. In this study, we synthesized a gemini QAC, PMT12-BF4 and found that it exerted unsurpassed broad-spectrum antifungal activity against drug susceptible and resistant Candida albicans, and other pathogenic fungi, with a minimal inhibitory concentration (MIC) at 1 or 2 μg/mL. These results indicated that PMT12 ...[more]