Structural Disconnections Explain Brain Network Dysfunction after Stroke.
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ABSTRACT:
SUBMITTER: Griffis JC
PROVIDER: S-EPMC7032047 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Structural Disconnections Explain Brain Network Dysfunction after Stroke.
Griffis Joseph C JC Metcalf Nicholas V NV Corbetta Maurizio M Shulman Gordon L GL
Cell reports 20190901 10
Stroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of activity synchronization, throughout distributed brain networks. It is often assumed that FC disruptions reflect damage to specific cortical regions. However, an alternative explanation is that they reflect the structural disconnection (SDC) of white matter pathways. Here, we compare these explanations using data from 114 stroke patients. Across multiple analyses, we find that SDC measures outperform focal ...[more]
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