Ontology highlight
ABSTRACT:
SUBMITTER: Mendez FM
PROVIDER: S-EPMC7032633 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Mendez Flor M FM Núñez Felipe J FJ Garcia-Fabiani Maria B MB Haase Santiago S Carney Stephen S Gauss Jessica C JC Becher Oren J OJ Lowenstein Pedro R PR Castro Maria G MG
Neuro-oncology 20200201 2
Diffuse intrinsic pontine glioma (DIPG) is a rare but deadly pediatric brainstem tumor. To date, there is no effective therapy for DIPG. Transcriptomic analyses have revealed DIPGs have a distinct profile from other pediatric high-grade gliomas occurring in the cerebral hemispheres. These unique genomic characteristics coupled with the younger median age group suggest that DIPG has a developmental origin. The most frequent mutation in DIPG is a lysine to methionine (K27M) mutation that occurs on ...[more]