Ontology highlight
ABSTRACT:
SUBMITTER: Owens EA
PROVIDER: S-EPMC7032661 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Bioconjugate chemistry 20190926 10
G-Quadruplex DNA has been recognized as a highly appealing target for the development of new selective chemotherapeutics, which could result in markedly reduced toxicity toward normal cells. In particular, the cyanine dyes that bind selectively to G-quadruplex structures without targeting duplex DNA have attracted attention due to their high amenability to structural modifications that allows fine-tuning of their biomolecular interactions. We have previously reported pentamethine and symmetric t ...[more]