Ontology highlight
ABSTRACT:
SUBMITTER: Lee BM
PROVIDER: S-EPMC7032734 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lee Brendon M BM Harold Liam K LK Almeida Deepak V DV Afriat-Jurnou Livnat L Aung Htin Lin HL Forde Brian M BM Hards Kiel K Pidot Sacha J SJ Ahmed F Hafna FH Mohamed A Elaaf AE Taylor Matthew C MC West Nicholas P NP Stinear Timothy P TP Greening Chris C Beatson Scott A SA Nuermberger Eric L EL Cook Gregory M GM Jackson Colin J CJ
PLoS pathogens 20200207 2
Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emergence of resistance, identify pre-existing resistant populations, and manage our use of antibiotics to effectively treat patients and prevent or slow the spread of resistance. Here we investigated the potential for resistance against the new antitubercular nitroimidazole prodrugs pretomanid and delamanid to emerge in Mycobacterium tuberculosis, the causative agent of t ...[more]