Embryonic geometry underlies phenotypic variation in decanalized conditions.
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ABSTRACT:
SUBMITTER: Huang A
PROVIDER: S-EPMC7032927 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Embryonic geometry underlies phenotypic variation in decanalized conditions.
Huang Anqi A Rupprecht Jean-François JF Saunders Timothy E TE
eLife 20200212
During development, many mutations cause increased variation in phenotypic outcomes, a phenomenon termed decanalization. Phenotypic discordance is often observed in the absence of genetic and environmental variations, but the mechanisms underlying such inter-individual phenotypic discordance remain elusive. Here, using the anterior-posterior (AP) patterning of the <i>Drosophila</i> embryo, we identified embryonic geometry as a key factor predetermining patterning outcomes under decanalizing muta ...[more]
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