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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.


ABSTRACT: Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

SUBMITTER: Erlendsson S 

PROVIDER: S-EPMC7032958 | biostudies-literature |

REPOSITORIES: biostudies-literature

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