Prospective diagnostic accuracy study of plasma soluble ST2 for diagnosis of acute aortic syndromes.

ABSTRACT: Acute aortic syndromes (AASs) are difficult to diagnose emergencies. Plasma soluble ST2 (sST2), a prognostic biomarker for heart failure, has been proposed as a diagnostic biomarker of AASs outperforming D-dimer, the current diagnostic standard. We performed a prospective diagnostic accuracy study of sST2 for AASs in the Emergency Department (ED). In 2017-2018, patients were enrolled if they had ?1 red-flag symptoms (chest/abdominal/back pain, syncope, perfusion deficit) and a clinical suspicion of AAS. sST2 was detected with the Presage® assay. Adjudication was based on computed tomography angiography (CTA) or on diagnostic outcome inclusive of 30-day follow-up. 297 patients were enrolled, including 88 with AASs. The median age was 67 years. In 162 patients with CTA, the median sST2 level was 41.7?ng/mL (IQR 29.4-103.2) in AASs and 34.6?ng/mL (IQR 21.4-51.5) in alternative diagnoses (P?=?0.005). In ROC analysis, the AUC of sST2 was 0.63, as compared to 0.82 of D-dimer (P?

SUBMITTER: Morello F 

PROVIDER: S-EPMC7033105 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature