Dataset Information

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.

ABSTRACT: The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping-individual-specific analysis of highly sampled human participants-we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. This approach revealed distinct subcortical zones of network specificity and multi-network integration. Integration zones were systematic, with convergence of cingulo-opercular control and somatomotor networks in the ventral intermediate thalamus (motor integration zones), dorsal attention and visual networks in the pulvinar, and default mode and multiple control networks in the caudate nucleus. The motor integration zones were present in every individual and correspond to consistently successful sites of deep brain stimulation (DBS; essential tremor). Individually variable subcortical zones correspond to DBS sites with less consistent treatment effects, highlighting the importance of PFM for neurosurgery, neurology, and psychiatry.

SUBMITTER: Greene DJ

PROVIDER: S-EPMC7035165 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.

Greene Deanna J DJ Marek Scott S Gordon Evan M EM Siegel Joshua S JS Gratton Caterina C Laumann Timothy O TO Gilmore Adrian W AW Berg Jeffrey J JJ Nguyen Annie L AL Dierker Donna D Van Andrew N AN Ortega Mario M Newbold Dillan J DJ Hampton Jacqueline M JM Nielsen Ashley N AN McDermott Kathleen B KB Roland Jarod L JL Norris Scott A SA Nelson Steven M SM Snyder Abraham Z AZ Schlaggar Bradley L BL Petersen Steven E SE Dosenbach Nico U F NUF

Neuron 20191210 4

The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping-individual-specific analysis of highly sampled human participants-we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. This approach ...[more]

PMID: 31836321

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Project description:Basal ganglia and the cerebellum are part of a densely interconnected network. While both subcortical structures process information in basically segregated loops that primarily interact in the neocortex, direct subcortical interaction has been recently confirmed by neuroanatomical studies using viral transneuronal tracers in non-human primate brains. The thalamus is thought to be the main relay station of both projection systems. Yet, our understanding of subcortical basal ganglia and cerebellar interconnectivity within the human thalamus is rather sparse, primarily due to limitation in the acquisition of in vivo tracing. Consequently, we strive to characterize projections of both systems and their potential overlap within the human thalamus by diffusion MRI and tractography. Our analysis revealed a decreasing anterior-to-posterior gradient for pallido-thalamic connections in: (1) the ventral-anterior thalamus, (2) the intralaminar nuclei, and (3) midline regions. Conversely, we found a decreasing posterior-to-anterior gradient for dentato-thalamic projections predominantly in: (1) the ventral-lateral and posterior nucleus; (2) dorsal parts of the intralaminar nuclei and the subparafascicular nucleus, and (3) the medioventral and lateral mediodorsal nucleus. A considerable overlap of connectivity pattern was apparent in intralaminar nuclei and midline regions. Notably, pallidal and cerebellar projections were both hemispherically lateralized to the left thalamus. While strikingly consistent with findings from transneuronal studies in non-human primates as well as with pre-existing anatomical studies on developmentally expressed markers or pathological human brains, our assessment provides distinctive connectional fingerprints that illustrate the anatomical substrate of integrated functional networks between basal ganglia and the cerebellum. Thereby, our findings furnish useful implications for cerebellar contributions to the clinical symptomatology of movement disorders.

Dataset Information

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.

Publications

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.

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