Ontology highlight
ABSTRACT:
SUBMITTER: Kallman A
PROVIDER: S-EPMC7035245 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Kallman Alyssa A Capowski Elizabeth E EE Wang Jie J Kaushik Aniruddha M AM Jansen Alex D AD Edwards Kimberly L KL Chen Liben L Berlinicke Cynthia A CA Joseph Phillips M M Pierce Eric A EA Qian Jiang J Wang Tza-Huei TH Gamm David M DM Zack Donald J DJ
Communications biology 20200221 1
Photoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor degeneration are not well understood. Treatment strategies would benefit from improved understanding of gene-expression patterns directing photoreceptor development, as many genes are implicated in both development and degeneration. Neural retina leucine zipper (NRL) is critical for rod photoreceptor genesis and degeneration, with NRL mutations known to cause enhanced S-cone syndrome and retinitis pigment ...[more]