Ontology highlight
ABSTRACT:
SUBMITTER: Asakawa K
PROVIDER: S-EPMC7035286 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Asakawa Kazuhide K Handa Hiroshi H Kawakami Koichi K
Nature communications 20200221 1
Cytoplasmic aggregation of TDP-43 characterizes degenerating neurons in most cases of amyotrophic lateral sclerosis (ALS). Here, we develop an optogenetic TDP-43 variant (opTDP-43), whose multimerization status can be modulated in vivo through external light illumination. Using the translucent zebrafish neuromuscular system, we demonstrate that short-term light stimulation reversibly induces cytoplasmic opTDP-43 mislocalization, but not aggregation, in the spinal motor neuron, leading to an axon ...[more]