Ontology highlight
ABSTRACT:
SUBMITTER: Estus S
PROVIDER: S-EPMC7035471 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Estus Steven S Shaw Benjamin C BC Devanney Nicholas N Katsumata Yuriko Y Press Eileen E EE Fardo David W DW
Acta neuropathologica 20190404 2
In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease. This finding sparked interest in this member of the sialic acid-binding immunoglobulin-type lectin family which is linked to innate immunity. Subsequent studies found that CD33 is expressed in microglia in the brain and then investigated the molecular mechanism underlying the CD33 genetic association with Alzheimer's disease. The allele that protects from Alzheimer's dis ...[more]