The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome.

ABSTRACT: Objective:To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. Methods:It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (FeNO). Results:Obesity was confirmed for the two groups with a total sample mean value of BMI?=?35.06?±?4.68?kg/m2. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93?±?14 vs. 79?±?12%), an abnormal DLCO (112?±?20 vs. 93?±?22%), and higher bronchial inflammation (18.40?±?9.20 vs. 31.30?±?13.60?ppb) (p < 0.05). Conclusion:Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation.

SUBMITTER: Rouatbi S 

PROVIDER: S-EPMC7035560 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature