Ontology highlight
ABSTRACT:
SUBMITTER: Tagliatti E
PROVIDER: S-EPMC7035618 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tagliatti Erica E Bello Oscar D OD Mendonça Philipe R F PRF Kotzadimitriou Dimitrios D Nicholson Elizabeth E Coleman Jeff J Timofeeva Yulia Y Rothman James E JE Krishnakumar Shyam S SS Volynski Kirill E KE
Proceedings of the National Academy of Sciences of the United States of America 20200203 7
Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca<sup>2+</sup> release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 Ca<sup>2+</sup> activation mechanism has been well-characterized, how Syt1 clamps transmitter release remains enigmatic. Here we show that C2B domain-dependent oligomerization provides the molecular basis for the Syt1 clamping function. This follows from the investigat ...[more]