The developing gut-lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model.
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SUBMITTER: Wedgwood S
PROVIDER: S-EPMC7035999 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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The developing gut-lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model.
Wedgwood Stephen S Warford Cris C Agvatisiri Sharleen R SR Thai Phung N PN Chiamvimonvat Nipavan N Kalanetra Karen M KM Lakshminrusimha Satyan S Steinhorn Robin H RH Mills David A DA Underwood Mark A MA
Pediatric research 20190919 3
<h4>Background</h4>Postnatal growth restriction (PNGR) in premature infants increases risk of pulmonary hypertension (PH). In a rodent model, PNGR causes PH, while combining PNGR and hyperoxia increases PH severity. We hypothesized that PNGR causes intestinal dysbiosis and that treatment with a probiotic attenuates PNGR-associated PH.<h4>Method</h4>Pups were randomized at birth to room air or 75% oxygen (hyperoxia), to normal milk intake (10 pups/dam) or PNGR (17 pups/dam), and to probiotic Lact ...[more]
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