Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Santamarina S
PROVIDER: S-EPMC7036007 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Garcia-Santamarina Sarela S Probst Corinna C Festa Richard A RA Ding Chen C Smith Aaron D AD Conklin Steven E SE Brander Søren S Kinch Lisa N LN Grishin Nick V NV Franz Katherine J KJ Riggs-Gelasco Pamela P Lo Leggio Leila L Johansen Katja Salomon KS Thiele Dennis J DJ
Nature chemical biology 20200113 3
Infection by the fungal pathogen Cryptococcus neoformans causes lethal meningitis, primarily in immune-compromised individuals. Colonization of the brain by C. neoformans is dependent on copper (Cu) acquisition from the host, which drives critical virulence mechanisms. While C. neoformans Cu<sup>+</sup> import and virulence are dependent on the Ctr1 and Ctr4 proteins, little is known concerning extracellular Cu ligands that participate in this process. We identified a C. neoformans gene, BIM1, t ...[more]