Ontology highlight
ABSTRACT:
SUBMITTER: Toomey S
PROVIDER: S-EPMC7036178 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Toomey Sinead S Carr Aoife A Mezynski Mateusz Janusz MJ Elamin Yasir Y Rafee Shereen S Cremona Mattia M Morgan Clare C Madden Stephen S Abdul-Jalil Khairun I KI Gately Kathy K Farrelly Angela A Kay Elaine W EW Kennedy Susan S O'Byrne Kenneth K Grogan Liam L Breathnach Oscar O Morris Patrick G PG Eustace Alexander J AJ Fay Joanna J Cummins Robert R O'Grady Anthony A Kalachand Roshni R O'Donovan Norma N Kelleher Fergal F O'Reilly Aine A Doherty Mark M Crown John J Hennessy Bryan T BT
Journal of translational medicine 20200222 1
<h4>Background</h4>An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutations within the patient's tumor that can confer clinical efficacy or drug resistance.<h4>Methods</h4>The aim of our study was to determine the type, frequency, overlap and functional proteomic effects of potentially targetable recurrent somatic hotspot m ...[more]