Ontology highlight
ABSTRACT:
SUBMITTER: Atif M
PROVIDER: S-EPMC7036337 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Atif Muhammad M Conti Filomena F Gorochov Guy G Oo Ye Htun YH Miyara Makoto M
Clinical & translational immunology 20200223 2
The induction of graft tolerance remains the holy grail of transplantation. This is important as chronic allograft dysfunction and the side effects of immunosuppression regimens place a major burden on the lives of transplant patients and their healthcare systems. This has mandated the need to understand the immunobiology of graft rejection and identify novel therapeutics. Regulatory T (Treg) cells play an important role in modulating pro-inflammatory microenvironments and maintaining tissue hom ...[more]