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Microarray data and pathway analyses of peripheral blood mononuclear cells from healthy subjects after a three weeks grape-rich diet.

ABSTRACT: Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. Moreover, fresh grape intake was found to influence the expression of many long non-coding RNA genes. The data can be valuable for researchers interested in nutrigenetics and nutrigenomics studies and are related to the research article "Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on PBMCs" [1].

SUBMITTER: Milella RA 

PROVIDER: S-EPMC7036720 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Microarray data and pathway analyses of peripheral blood mononuclear cells from healthy subjects after a three weeks grape-rich diet.

Milella Rosa Anna RA   Gasparro Marica M   Alagna Fiammetta F   Cardone Maria Francesca MF   Rotunno Silvia S   Ammollo Concetta Tiziana CT   Semeraro Fabrizio F   Tullo Apollonia A   Marzano Flaviana F   Catalano Domenico D   Antonacci Donato D   Colucci Mario M   D'Elia Domenica D  

Data in brief 20200212

Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and prot  ...[more]

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