Ontology highlight
ABSTRACT:
SUBMITTER: Al Matarneh CM
PROVIDER: S-EPMC7036904 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200125 3
Three series of fused pyrrolophenanthroline derivatives were designed as analogues of phenstatin and synthesized in two steps starting with 1,7-phenanthroline, 4,7-phenanthroline and 1,10-phenanthroline, respectively. Two (Compounds <b>8a</b> and <b>11c</b>) of the four compounds tested against a panel of sixty human cancer cell lines of the National Cancer Institute (NCI) exhibited significant growth inhibition activity on several cell lines. Compound <b>11c</b> showed a broad spectrum in terms ...[more]