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Understanding the Solution Behavior of Epinephrine in the Presence of Toxic Cations: A Thermodynamic Investigation in Different Experimental Conditions.


ABSTRACT: The interactions of epinephrine ((R)-(-)-3,4-dihydroxy-?-(methylaminomethyl)benzyl alcohol; Eph-) with different toxic cations (methylmercury(II): CH3Hg+; dimethyltin(IV): (CH3)2Sn2+; dioxouranium(VI): UO22+) were studied in NaClaq at different ionic strengths and at T = 298.15 K (T = 310.15 K for (CH3)2Sn2+). The enthalpy changes for the protonation of epinephrine and its complex formation with UO22+ were also determined using isoperibolic titration calorimetry: HHL = -39 ± 1 kJ mol-1, HH2L = -67 ± 1 kJ mol-1 (overall reaction), HML = -26 ± 4 kJ mol-1, and HM2L2(OH)2 = 39 ± 2 kJ mol-1. The results were that UO22+ complexation by Eph- was an entropy-driven process. The dependence on the ionic strength of protonation and the complex formation constants was modeled using the extended Debye-Hückel, specific ion interaction theory (SIT), and Pitzer approaches. The sequestering ability of adrenaline toward the investigated cations was evaluated using the calculation of pL0.5 parameters. The sequestering ability trend resulted in the following: UO22+ >> (CH3)2Sn2+ > CH3Hg+. For example, at I = 0.15 mol dm-3 and pH = 7.4 (pH = 9.5 for CH3Hg+), pL0.5 = 7.68, 5.64, and 2.40 for UO22+, (CH3)2Sn2+, and CH3Hg+, respectively. Here, the pH is with respect to ionic strength in terms of sequestration.

SUBMITTER: Crea F 

PROVIDER: S-EPMC7037007 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Understanding the Solution Behavior of Epinephrine in the Presence of Toxic Cations: A Thermodynamic Investigation in Different Experimental Conditions.

Crea Francesco F   De Stefano Concetta C   Irto Anna A   Lando Gabriele G   Materazzi Stefano S   Milea Demetrio D   Pettignano Alberto A   Sammartano Silvio S  

Molecules (Basel, Switzerland) 20200124 3


The interactions of epinephrine ((<i>R</i>)-(-)-3,4-dihydroxy-α-(methylaminomethyl)benzyl alcohol; <i>Eph</i><sup>-</sup>) with different toxic cations (methylmercury(II): CH<sub>3</sub>Hg<sup>+</sup>; dimethyltin(IV): (CH<sub>3</sub>)<sub>2</sub>Sn<sup>2+</sup>; dioxouranium(VI): UO<sub>2</sub><sup>2+</sup>) were studied in NaCl<sub>aq</sub> at different ionic strengths and at <i>T</i> = 298.15 K (<i>T</i> = 310.15 K for (CH<sub>3</sub>)<sub>2</sub>Sn<sup>2+</sup>). The enthalpy changes for the  ...[more]

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