Ontology highlight
ABSTRACT:
SUBMITTER: Atzori A
PROVIDER: S-EPMC7037162 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Atzori Alessio A Malloci Giuliano G Cardamone Francesca F Bosin Andrea A Vargiu Attilio Vittorio AV Ruggerone Paolo P
International journal of molecular sciences 20200129 3
The drug/proton antiporter AcrB, engine of the major efflux pump AcrAB(Z)-TolC of <i>Escherichia coli</i> and other bacteria, is characterized by its impressive ability to transport chemically diverse compounds, conferring a multi-drug resistance (MDR) phenotype. Although hundreds of small molecules are known to be AcrB substrates, only a few co-crystal structures are available to date. Computational methods have been therefore intensively employed to provide structural and dynamical fingerprint ...[more]