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The Endocannabinoid System: A Target for Cancer Treatment.

ABSTRACT: In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.

SUBMITTER: Laezza C 

PROVIDER: S-EPMC7037210 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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The Endocannabinoid System: A Target for Cancer Treatment.

Laezza Chiara C   Pagano Cristina C   Navarra Giovanna G   Pastorino Olga O   Proto Maria Chiara MC   Fiore Donatella D   Piscopo Chiara C   Gazzerro Patrizia P   Bifulco Maurizio M  

International journal of molecular sciences 20200123 3

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further  ...[more]