Ontology highlight
ABSTRACT:
SUBMITTER: Haeger A
PROVIDER: S-EPMC7037234 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Haeger Anna A Alexander Stephanie S Vullings Manon M Kaiser Fabian M P FMP Veelken Cornelia C Flucke Uta U Koehl Gudrun E GE Hirschberg Markus M Flentje Michael M Hoffman Robert M RM Geissler Edward K EK Kissler Stephan S Friedl Peter P
The Journal of experimental medicine 20200101 1
Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To identify how invasion and resistance programs cooperate, we used intravital microscopy of orthotopic sarcoma and melanoma xenografts. We demonstrate that these tumors invade collectively and that, specifically, cells within the invasion zone acquire increased resistance to radiotherapy, rapidly normalize DNA damage, and preferentially survive. U ...[more]