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Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process.


ABSTRACT: An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.

SUBMITTER: Meng C 

PROVIDER: S-EPMC7037277 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process.

Meng Chenkai C   Niu Haolin H   Ning Juehan J   Wu Wengang W   Yi Jun J  

Molecules (Basel, Switzerland) 20200130 3


An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group. ...[more]

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