Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC7037308 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lee Shannon S Rauch Jens J Kolch Walter W
International journal of molecular sciences 20200207 3
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role of MAPK pathways in modulating drug sensitivity and resistance in cancer. We briefly discuss new findings in the extracellular signaling-regulated kinase (ERK) pathway, but mainly focus on the mechanisms how stress activated MAPK pathways, such as p38 MAPK and the Jun N-terminal kinases (JNK), impact ...[more]